Due to the high clinical variability in presentation of Déjerine-Roussy syndrome, it is impossible to predict which patients with a thalamic stroke will develop pain. Stroke and pain can sometimes result in Dejerine-Roussy syndrome. Available treatments include antidepressants, anticonvulsants, and. Improvement in neurological signs and symptoms of thalamic syndrome ( Dejerine-Roussy Syndrome) due to a stroke 20 years previously (in.

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The disorder develops following damage to the central nervous system — the brain, brainstem or spinal cord.

Instead, CRPS can be defined as peripheral neuropathic pain with a strong inflammatory component. The risk of lethal brain hemorrhage is small, but real.

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Lamotrigine is an anti-seizure drug anticonvulsant. Unsourced material may be challenged and removed. Symptoms are generally not treatable with ordinary analgesics. Intravenous ketamine is reserved for the refractory cases of central poststroke pain.

Dejerine-Roussy Syndrome

Diagnosis and assessment of neuropathic pain. Many chemical medications have been used for a broad range of neuropathic pain including Dejerine—Roussy syndrome.

Alone we are rare. Opioids such as morphine or levorphanol are not effective in the vast majority of cases and are actually contraindicated for most patients. Weeks to months later, numbness can develop into severe and chronic pain that is not proportional to an environmental stimulus, called dysesthesia or allodynia.

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Dé​jerine-Roussy syndrome | Radiology Reference Article |

Dejerine-Roussy is a rare pain syndrome. Although the thalamus is the location of the lesion implicated in this syndrome, central post-stroke pain can also occur due to lesions at any level of the spinothalamic pathwaysuch as in patients with the lateral medullary syndrome or with cortical lesions 2,7.


Less commonly, some patients develop severe ongoing pain with little or no stimuli. This understanding points to new experimental therapeutic strategies see below. NSAIDs generally provide little to no relief for individuals with central pain syndrome.

The imbalance in sensation characterized by Dejerine—Roussy syndrome can be argued through a model addressing a system of inputs and outputs that the brain must constantly process throughout life, suggesting latent plasticity. This page was last edited on 6 Octoberat The Journal of Pain.

Turn recording back on. Dejerine Roussy Syndrome – StatPearls. Kumar G, Soni CR.

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General Discussion Summary Central pain syndrome is a neurological disorder caused by damage to the sensory pathways of the central nervous system CNS. Symptoms are typically lateralized and may include vision loss or loss of balance position sense. Affected individuals may become hypersensitive to painful stimuli.

The incidence and duration of central post-stroke pain are not related to gender or age of the patient nor the side of the lesion. For example, affected individuals may experience pain when touched, even when lightly touched. However, more research is necessary to determine the long-term safety and effectiveness of this procedure as a potential therapy for individuals with central pain syndrome.

Intracerebral hemorrhage can precede central post-stroke pain in the legs because of the pattern of arrangement of fibers to face, arm, trunk, and leg is mediolateral, in the ventral posterior nucleus of the thalamus. Stroke patients with central post-stroke pain should be enrolled for rehabilitation and management of other co-morbidities.


Particularly, the posterior insula has been mapped to correlate to pain experienced by an individual. Two drugs, amitriptyline and lamotrigine, have proven beneficial in controlled trials, especially for individuals with central pain of brain origin. The lesions, usually present in one hemisphere of the brain, most often cause an initial lack of sensation and tingling in the opposite side of the body. Encephalomyelitis Acute disseminated Myalgic Meningoencephalitis. Cerebrovascular diseases Syndromes affecting the nervous system Thalamus.

Non-invasive forms of cortical stimulation such as transcranial magnetic stimulation TMS or transcranial direct current stimulation tDCS have been employed in the management of CPS, but data show that their efficacy is not on a par with neurosurgical intervention. Treatment Treatment for central pain syndrome remains unsatisfactory in that, although most patients find some relief, complete control remains infrequent.

Lesions of spinal cord and brain. Post-stroke pain case study: The ventral posterolateral nucleus of the thalamus has an intrinsic network of GABAergic neurons, which causes the intrinsic inhibition of ventral posterolateral nucleus.