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FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM PDF

Abstract: The medicated chewing gum containing methyl prednisolone IP may be an excellent formulation to treat oral ulcer caused by the consumption of. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. The new drug delivery system was obtained , at room. Formulation and evaluation of medicated chewing gum as antiplaque and antibacterial agent. S Vasudha Lakshmi1, Hemant KS Yadav1*, KP Mahesh2, Swati.

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Urinary excretion profile showed that within the short span of time 1. Formulaation of Drug Delivery and Therapeutics7 4 Chewing gums were prepared by using chlorhexidine and various proportions of gum base and chitosan.

Chewing gumChitosanChlorhexidineDental Caries. Skip to main content Skip to main navigation menu Skip to site footer. Abstract An attempt has been made to formulate new chewing gum for Dolasetron. From this study, we can conclude that the medicated ebaluation formulation can be a better choice in the coming years which provides several benefits and also benefits commercially.

The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment. The dose of chlorhexidine can be reduced significantly when used along with chitosan. Better medidated of formulation and faster release of drug in saliva was obtained with glycerol F IIIand Castor oil F II but castor oil shows optimum result against glycerol combination, which is formulation II.

The in vivo forkulation on human volunteers were carried out for optimized formulation F5 containing chitosan and antibacterial agent which showed a better reduction in the bacterial count and gingival index.

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Open Access Pharmaceutics Research Journal. Guidelines Upcoming Special Issues. Journal of Current Pharma Research ; 4 4: Analysis of variance revealed significant differences between subjects receiving F1 and F5 for antiplaque activity. A Modern Era of Drug Delivery, international research journal of pharmacy, ; 2 The aim of this study was to formulate chewing gum using chlorhexidine and chitosan and to prove its antibacterial and antiplaque properties effectively at low doses of chlorhexidine.

Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication.

Formulation And Evaluation Of Medicated Chewing Gum Of Metaclopramide |

Chitosan containing chewing gum has a greater antibacterial effect compared with gums containing only wnd. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Metaclopramide for bypassing the hepatic first pass effect.

The resulting chewing gum comprises a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing. Ann Jose ankara escort.

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The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent evaluatlon plasticizers, which provide smooth appearance and flexibility during storage and chewing. His Research Guide is Dr. As the proportion of gum base was increased, an increase in hardness of the chewing gum was observed.

The formulation, which evaluatiion highest concentration of chitosan, showed more in vitro release compared to other formulation. In the present study, an attempt has been made to formulate the chewing gum of Metaclopramide.

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FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF DOLASETRON AS AN ANTIEMETIC AGENT

Presently he is an M. Volume 7, Issue 4, Guj The volunteers were visually examined for presence or absence of gingival erythema, gingival edema and gingival bleeding and the antibacterial activity was assessed by the reduction in bacterial count in the plaque samples.

Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Dolasetron for bypassing the hepatic first pass effect.

The prepared gums were evaluated for physical parameters, compatibility studies, drug content, moisture content, stability studies and in vitro drug-release testing.

Vol 7 No 4 chewibg Madan N, Rathnam A. Hence, Metaclopramide chewing gum can be considered as a better formulation for the buccal drug delivery system, in which drug is absorbed buccally and reaches the systemic circulation via jugular vein. Announcements Editorial Board Indexing Contact.

Authors who publish with this journal agree to the following terms: Pharmaceutical Sciences Journals Ann Jose ankara escort. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. An attempt has been made to formulate new chewing gum for Dolasetron.

Naik H, Gupta S. Agri and Aquaculture Journals Dr.