In the past decade, HIFU ablation has emerged as a modality for palliative treatment of pancreatic tumors. Multiple preclinical and non-randomized clinical trials. HIFU appears to be an effective tool for pain palliation in advanced pancreatic cancer. Studies assessing treatment in patients with pancreatic. Request PDF on ResearchGate | HIFU for Palliative Treatment of Pancreatic Cancer | High intensity focused ultrasound (HIFU) is a novel.

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HIFU efficacy on tumour growth control is still largely debated. Radiation force and streaming Radiation force is exerted on an object when a wave is either absorbed or reflected from that object. Experimental ablation of the pancreas with high intensity focused ultrasound HIFU in a porcine model.

Pain response was routinely assessed during follow-up visits using a numeric pain scale The treatment was performed with computerised axial scanning and power Doppler to evaluate the effect of ablation on the artery engaged.

HIFU for palliative treatment of pancreatic cancer

SMA — superior mesenteric artery. In terms of tumor visualization, both MRI and sonography can provide satisfactory images; MRI is sometimes superior in obese patients 39but is more expensive and labor-intensive. The tumor was histologically verified as an cncer. There are currently two imaging methods employed in commercially available HIFU devices: Can’t read the image?

HIFU for Palliative Treatment of Pancreatic Cancer.

Cavitation threshold has been measured in different tissues in a number of studies, but there is still no agreement 21 – 23 Complications included superficial skin burns 3. In the function scales and GHS scale higher scores represent a better level of functioning.


After a multidisciplinary discussion involving interventional radiologists, surgeons, and medical oncologists, we decided to choose HIFU for the aforementioned reasons because of its one-shot technique, its previous favourable results in unresectable pancreatic cancer, and its greater suitability to be combined with chemotherapy when compared with radiation therapy.

He underwent an upper gastrointestinal GI endoscopy showing a submucosal nodule in the gastric antrum, and an abdomen ultrasonography US showing multiple gallstones and a 3 cm pancreatic body lesion. Analgesic effect of high intensity focused ultrasound therapy for unresectable pancreatic cancer. In the absence of literature data, a first-line therapy with gemcitabine plus cisplatin was delivered without benefit as shown from clinical worsening and radiological disease progression [ 6 ].

The interval spacing in the z direction is mm. Wang X, Sun JZ. Pain response and complications were observed after completion of HIFU treatments and at one month posttreatment. Substantial tumor-related pain reduction was achieved in most cases after HIFU treatment, and no significant side-effects were observed. HIFU ablation is a non-invasive technique used for the control of localised tumour mass.

The pancreatic tumor had infiltrated the superior mesenteric artery and showed slight volume increase Figure 2b and Figure 3. The treatment was performed with vertical scanning mode separated by 5mm-distance between each slice.

The water bladder was filled with degassed water and coupled to the skin with ultrasound coupling gel. Visit for more related articles at JOP.

Pain is often reported by patients with advanced disease, and palliative treatment methods are commonly employed and include opioid therapy and celiac plexus neurolysis 4. There were no patients who developed clinical pancreatitis as a result of HIFU treatment and there were no treatment related deaths. The median overall survival of patients, however, pandreatic from pslliative to 6 months [ 6 ].


This study was performed under general anesthesia, after 3-days of bowel preparation to avoid the presence of panrceatic gas in the acoustic pathway. Informed written consent for treatment was obtained from each patient and the study protocol conforms to the ethical guidelines of the “World Medical Association Declaration of Helsinki – Ethical Principles for Medical Research Involving Human Subjects” off by the 18th WMA General Assembly, Helsinki, Finland, Juneas revised in Tokyoas reflected in a priori approval by the ethics review committee.

Orsi F et al High-intensity focused ultrasound ablation: Pain control is an important component of palliation and is commonly performed using opioid therapy and celiac plexus neurolysis.

However, it was shown that most damage occurs as the bubble rapidly collapses and the vessel wall is bent inward or invaginated, causing high amplitude shear stress Preclinical in vivo evaluation of an extracorporeal HIFU device for ablation of pancreatic tumors.

Workshop on Interaction of Ultrasound treatmnt Biological Tissues. Haar GT, Coussios C.

The patients fasted beginning the night palliwtive a HIFU procedure and the placement of a nasogastric tube was required prior to two HIFU treatment sessions in order to remove gas from the stomach that was obscuring the tumor.

If the bubble collapse occurs next to a cell, the jets may be powerful enough to cause disruption of the cell membrane 25 HIFU has been used clinically in China since to treat over 20, patients for a wide range of indications with an excellent safety profile.